Acetaldehyde-reinforcing effects: a study on oral self-administration behavior

Acetaldehyde-reinforcing effects: a study on oral self-administration behavior

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Acetaldehyde (ACD) is the first metabolite of ethanol.Although, the role of ACD in ethanol addiction has been controversial, there are data showing a relationship.The objective of the current study was further to test the hypothesis FOOTED TRAY that ACD itself is reinforcing.For this reason, we carried out a study on operant oral ACD self-administration.Wistar rats were trained to self-administer tap water or ACD by nose-poking in daily 30 mins sessions for 15 consecutive days.

Response on active nose-poke caused delivery of ACD solution or tap water, whereas responses on inactive nose-poke had no consequences.The results show that ACD maintains oral self-administration behavior and rates of active nose-pokes significantly higher than tap water.The dose-response plot for oral ACD self-administration is a “bell-shaped” curve suggesting reinforcing properties only in a limited range of doses.Furthermore, rats self-administering ACD show a deprivation effect upon ACD removal and gradually reinstated active nose-poke response when ACD was reintroduced.Overall, this study shows that ACD is orally self-administered and further supports the hypothesis that ACD possesses reinforcing properties, which suggests that some of the pharmacological effects attributed to ethanol may result from the its biotransfomation SOAP 3 IN 1 UNSCENTED into ACD, thereby supporting an active involvement of ACD in ethanol addiction.